Publications

2025

  1. Ashraf KU, Bunoro-Batista M, Ansell TB, Punetha A, Rosario-Garrido S, Firlar E, et al. Structural basis of undecaprenyl phosphate glycosylation leading to polymyxin resistance in Gram-negative bacteria. bioRxiv. 2025.
  2. Chu HF, Tong L. Molecular basis for the interaction between Saccharomyces cerevisiae Rtt103 and the Rat1-Rai1 complex. Nat Commun. 2025.
  3. Feldman J, Ramos ASF, Vu M, Maurer DP, Rosado VC, Lingwood D, et al. Human naive B cells recognize prepandemic influenza virus hemagglutinins. Sci Immunol. 2025.
  4. Ganguly C, Martin L, Aribam S, Thomas LM, Rajan R. Helical transition of the bridge helix of Cas12a is an allosteric regulator of R-loop formation and RuvC activation. bioRxiv. 2025.
  5. Haudiquet M, Chakravarti A, Zhang Z, Ramirez JL, Herrero Del Valle A, Olinares PDB, et al. Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery. bioRxiv. 2025.
  6. Herbine K, Nayak AR, Zamudio-Ochoa A, Temiakov D. Structural Basis for Promoter Recognition and Transcription Factor Binding and Release in Human Mitochondria. bioRxiv. 2025.
  7. Honda M, Razzaghi M, Gaur P, Malacaria E, Marozzi G, Di Biagi L, et al. The RAD52 double-ring remodels replication forks restricting fork reversal. Nature. 2025.
  8. Huang J, Tong L. Molecular insights into the overall architecture of human rixosome. Nat Commun. 2025.
  9. Jaiswal R, Braud B, Hernandez-Ramirez KC, Santosh V, Washington A, Escalante CR.Cryo-EM structure of AAV2 Rep68 bound to integration site AAVS1: insights into the mechanism of DNA melting. Nucleic Acids Res. 2025.
  10. Khanra NK, Wang C, Delgado BD, Long SB. Structure of the human TWIK-2 potassium channel and its inhibition by pimozide. bioRxiv. 2025.
  11. Mancl JM, Wu X, Zhao M, Tang WJ. Dimerization and dynamics of angiotensin-I converting enzyme revealed by cryoEM and MD simulations.
    bioRxiv. 2025.
  12. Maurer DP, Vu M, Ramos ASF, Dugan HL, Khalife P, Geoghegan JC, et al. Conserved sites on the influenza H1 and H3 hemagglutinin recognized by human antibodies. Science Advances. 2025.
  13. Neuberger A, Shalygin A, Trofimov YA, Veretenenko, II, Nadezhdin KD, Krylov NA, et al. Structure-function analyses of human TRPV6 ancestral and derived haplotypes. Structure. 2025.
  14. Padi SKR, Godek RJ, Peti W, Page R. Cryo-EM structures of PP2A:B55 with p107 and Eya3 define substrate recruitment. Nat Struct Mol Biol. 2025.
  15. Pant S, Tam SW, Long SB. The pentameric chloride channel BEST1 is activated by extracellular GABA. Proc Natl Acad Sci U S A. 2025.
  16. Rao V, Sapse I, Cohn H, Yoo DK, Tong P, Clark J, et al. Convergent and clonotype-enriched mutations in the light chain drive affinity maturation of a public antibody. bioRxiv. 2025.
  17. Santarossa CC, Li Y, Yousef S, Hasdemir HS, Rodriguez CC, Haase MB, et al. LetA defines a structurally distinct transporter family involved in lipid trafficking. bioRxiv. 2025.
  18. Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, et al. Snapshots of acyl carrier protein shuttling in human fatty acid synthase. Nature. 2025.
  19. Tucci FJ, Rosenzweig AC. Structures of methane and ammonia monooxygenases in native membranes. Proc Natl Acad Sci U S A. 2025.
  20. Xu D, Thomas WC, Burnim AA, Ando N. Conformational landscapes of a class I ribonucleotide reductase complex during turnover reveal intrinsic dynamics and asymmetry. Nat Commun. 2025.
  21. Zhao Y, Xu C, Chen X, Jin H, Li H. Structural basis for hygromycin B inhibition of yeast pseudouridine-deficient ribosomes. Sci Adv. 2025.
  22. Zhao Y, Vidossich P, Forbush B, Ma J, Rinehart J, De Vivo M, et al. Structural basis for human NKCC1 inhibition by loop diuretic drugs.
    EMBO J. 2025.

2024

  1. Aragon M, Bowman SEJ, Chen CH, de la Cruz MJ, Decato DA, Eng ET, et al. Applying 3D ED/MicroED workflows toward the next frontiers. Acta Crystallogr C Struct Chem. 2024.
  2. Baca CF, Majumder P, Hickling JH, Ye L, Teplova M, Brady SF, et al. The CRISPR-associated adenosine deaminase Cad1 converts ATP to ITP to provide antiviral immunity. Cell. 2024.
  3. Baldwin ET, van Eeuwen T, Hoyos D, Zalevsky A, Tchesnokov EP, Sanchez R, et al. Structures, functions and adaptations of the human LINE-1 ORF2 protein. Nature. 2024.
  4. Begley M, Aragon M, Baker RW. A structure-based mechanism for initiation of AP-3 coated vesicle formation. bioRxiv. 2024.
  5. Bha Padi SKR, Vos MR, Godek RJ, Fuller JR, Kruse T, Hein JB, et al. Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19. Nature. 2024.
  6. Clark J, Hoxie I, Adelsberg DC, Sapse IA, Andreata-Santos R, Yong JS, et al. Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination. bioRxiv. 2024.
  7. Decato D, Palatinus L, Stierle A, Stierle D. Absolute structure determination of Berkecoumarin by X-ray and electron diffraction. Acta Crystallogr C Struct Chem. 2024.
  8. Ennist NM, Wang S, Kennedy MA, Curti M, Sutherland GA, Vasilev C, et al. De novo design of proteins housing excitonically coupled chlorophyll special pairs. Nat Chem Biol. 2024.
  9. Feng S, Aplin C, Nguyen TT, Milano SK, Cerione RA. Filament formation drives catalysis by glutaminase enzymes important in cancer progression. Nat Commun. 2024.
  10. Gao X, Yeh HI, Yang Z, Fan C, Jiang F, Howard RJ, et al. Allosteric inhibition of CFTR gating by CFTRinh-172 binding in the pore. Nat Commun. 2024.
  11. Gangwar SP, Yelshanskaya MV, Nadezhdin KD, Yen LY, Newton TP, Aktolun M, et al. Kainate receptor channel opening and gating mechanism. Nature. 2024.
  12. Gonzalez-Del Pino GL, Walsh RM, Atanasiu D, Cairns TM, Saw WT, Cohen GH, et al. Allosteric mechanism of membrane fusion activation in a herpesvirus. bioRxiv. 2024.
  13. Hirano S, Altae-Tran H, Kannan S, Macrae RK, Zhang F. Structural determinants of DNA cleavage by a CRISPR HNH-Cascade system. Mol Cell. 2024.
  14. Hou K, Ge P, Sawaya MR, Dolinsky JL, Yang Y, Jiang YX, et al. How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer’s disease brain by a strain-relief mechanism. bioRxiv. 2024.
  15. Huddy TF, Hsia Y, Kibler RD, Xu J, Bethel N, Nagarajan D, et al. Blueprinting extendable nanomaterials with standardized protein blocks. Nature. 2024.
  16. Jaiswal R, Santosh V, Braud B, Washington A, Escalante CR. Cryo-EM Structure of AAV2 Rep68 bound to integration site AAVS1: Insights into the mechanism of DNA melting. bioRxiv. 2024.
  17. Jia L, Ruben EA, Suarez HJ, Olsen SK, Wasmuth EV. Single particle cryo-electron microscopy with an enhanced 200 kV cryo-TEM configuration achieves near-atomic resolution. bioRxiv. 2024.
  18. Lampe GD, Liang AR, Zhang DJ, Fernandez IS, Sternberg SH. Structure-guided engineering of type I-F CASTs for targeted gene insertion in human cells. bioRxiv. 2024.
  19. Li J, Li Y, Koide A, Kuang H, Torres VJ, Koide S, et al. Proton-coupled transport mechanism of the efflux pump NorA. Nat Commun. 2024.
  20. Lujan Hernandez AG, Laughlin ZT, Patel A, Yuan TZ, Nugent RL, Axelrod F, et al. Structural basis of SARS-Cov-2 spike recognition by engineered synthetic multivalent VHH antibodies. bioRxiv. 2024.
  21. Miller RC, Patterson MG, Bhatt N, Pei X, Ando N. Mechanism of Nucleotide-Dependent Allosteric Regulation in Escherichia coli Aspartate Transcarbamoylase. bioRxiv. 2024.
  22. Nandi S, Dey D, Srinivas P, Dunham CM, Conn GL. DISTANT RIBOSE 2′-O-METHYLATION OF 23S rRNA HELIX 69 PRE-ORDERS THE CAPREOMYCIN DRUG BINDING POCKET AT THE RIBOSOME SUBUNIT INTERFACE. bioRxiv. 2024.
  23. Nguyen BA, Singh V, Afrin S, Yakubovska A, Wang L, Ahmed Y, et al. Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nat Commun. 2024.
  24. Olia AS, Prabhakaran M, Harris DR, Cheung CS, Gillespie RA, Gorman J, et al. Anti-idiotype isolation of a broad and potent influenza A virus-neutralizing human antibody. Front Immunol. 2024.
  25. Owji AP, Dong J, Kittredge A, Wang J, Zhang Y, Yang T. Neurotransmitter-bound bestrophin channel structures reveal small molecule drug targeting sites for disease treatment. Nat Commun. 2024.
  26. Pant S, Tam SW, Long SB. The pentameric chloride channel BEST1 is activated by extracellular GABA. bioRxiv. 2024.
  27. Petassi M, Shin Y, Jessop AM, Morse K, Kim SY, Matei R, et al. Lineage-specific amino acids define functional attributes of the protomer-protomer interfaces for the Rad51 and Dmc1 recombinases. bioRxiv. 2024.
  28. Rastegarpouyani H, Hojjatian A, Taylor KA. Two Forms of Thick Filament in the Flight Muscle of Drosophila melanogaster.
  29. Sharma S, Luo M, Patel H, Mueller DM, Liao M. Conformational ensemble of yeast ATP synthase at low pH reveals unique intermediates and plasticity in F(1)-F(o) coupling. Nat Struct Mol Biol. 2024.
  30. Wang L, Hoang A, Gil-Iturbe E, Laganowsky A, Quick M, Zhou M. Mechanism of anion exchange and small-molecule inhibition of pendrin. Nat Commun. 2024.
  31. Wang S, Favor A, Kibler R, Lubner J, Borst AJ, Coudray N, et al. Bond-centric modular design of protein assemblies.
    bioRxiv. 2024.
  32. Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, et al. Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Nature. 2024.
  33. Xu D, Ando N. Miffi: Improving the accuracy of CNN-based cryo-EM micrograph filtering with fine-tuning and Fourier space information. J Struct Biol. 2024.
  34. Xu P, Saito M, Faure G, Maguire S, Chau-Duy-Tam Vo S, Wilkinson ME, et al. Structural insights into the diversity and DNA cleavage mechanism of Fanzor. Cell. 2024.
  35. Yang R, Ko YH, Li F, Lokareddy RK, Hou CD, Kim C, et al. Structural basis for nuclear import of hepatitis B virus (HBV) nucleocapsid core. Sci Adv. 2024.
  36. Zhao Y, Schubert H, Blakely A, Forbush B, Smith MD, Rinehart J, et al. Structural bases for Na(+)-Cl(-) cotransporter inhibition by thiazide diuretic drugs and activation by kinases. Nat Commun. 2024.
  37. Zhao Y, Xu C, Chen X, Jin H, Li H. Unveil the Molecular Interplay between Aminoglycosides and Pseudouridine in IRES Translation.
    bioRxiv. 2024.
  38. Zilberg G, Parpounas AK, Warren AL, Yang S, Wacker D. Molecular basis of human trace amine-associated receptor 1 activation. Nat Commun. 2024.
  39. Zilberg G, Parpounas AK, Warren AL, Fiorillo B, Provasi D, Filizola M, et al. Structural insights into the unexpected agonism of tetracyclic antidepressants at serotonin receptors 5-HT(1e)R and 5-HT(1F)R. Sci Adv. 2024.
  40. Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, et al. Promiscuous G-protein activation by the calcium-sensing receptor. Nature. 2024.

2023

  1. Atanasoff KE, Brambilla L, Adelsberg DC, Kowdle S, Stevens CS, Hung CT, et al. An in vitro experimental pipeline to characterize the binding specificity of SARS-CoV-2 neutralizing antibodies. bioRxiv. 2023.
  2. Capper MJ, Yang S, Stone AC, Vatansever S, Zilberg G, Mathiharan YK, et al. Substrate binding and inhibition of the anion exchanger 1 transporter. Nat Struct Mol Biol. 2023.
  3. Consalvo CD, Aderounmu AM, Donelick HM, Aruscavage PJ, Eckert DM, Shen PS, et al. C. elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA. bioRxiv. 2023.
  4. Edman NI, Redler RL, Phal A, Schlichthaerle T, Srivatsan SR, Etemadi A, et al. Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies. bioRxiv. 2023.
  5. Feng S, Aplin C, Nguyen TT, Cerione RA. Filament formation by glutaminase enzymes drives catalysis. bioRxiv. 2023.
  6. Frey SJ, Carreno JM, Bielak D, Arsiwala A, Altomare CG, Varner C, et al. Nanovaccines Displaying the Influenza Virus Hemagglutinin in an Inverted Orientation Elicit an Enhanced Stalk-Directed Antibody Response. Adv Healthc Mater. 2023.
  7. Gangwar SP, Yen LY, Yelshanskaya MV, Sobolevsky AI. Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel. Cell reports. 2023.
  8. Gibbs E, Klemm E, Seiferth D, Kumar A, Ilca SL, Biggin PC, et al. Conformational transitions and allosteric modulation in a heteromeric glycine receptor. Nat Commun. 2023.
  9. Han BG, Avila-Sakar A, Remis J, Glaeser RM. Challenges in making ideal cryo-EM samples. Curr Opin Struct Biol. 2023.
  10. Henderson R, Zhou Y, Stalls V, Wiehe K, Saunders KO, Wagh K, et al. Structural basis for breadth development in the HIV-1 V3-glycan targeting DH270 antibody clonal lineage. Nat Commun. 2023.
  11. Hoang Trinh TK, Catalano C, Guo Y. Fabrication of membrane proteins in the form of native cell membrane nanoparticles using novel membrane active polymers. Nanoscale Adv. 2023.
  12. Hu Z, Zheng X, Yang J. Conformational trajectory of allosteric gating of the human cone photoreceptor cyclic nucleotide-gated channel. Nat Commun. 2023.
  13. Huddy TF, Hsia Y, Kibler RD, Xu J, Bethel N, Nagarajan D, et al. Blueprinting expandable nanomaterials with standardized protein building blocks. bioRxiv. 2023.
  14. Kulczyk AW, Sorzano COS, Grela P, Tchorzewski M, Tumer NE, Li XP. Cryo-EM structure of Shiga toxin 2 in complex with the native ribosomal P-stalk reveals residues involved in the binding interaction. J Biol Chem. 2023.
  15. Leonhardt SA, Purdy MD, Grover JR, Yang Z, Poulos S, McIntire WE, et al. Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry. Nat Commun. 2023.
  16. Li F, Hou CD, Lokareddy RK, Yang R, Forti F, Briani F, et al. High-resolution cryo-EM structure of the Pseudomonas bacteriophage E217. Nat Commun. 2023.
  17. Malone BF, Perry JK, Olinares PDB, Lee HW, Chen J, Appleby TC, et al. Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature. 2023.
  18. Molodtsov V, Wang C, Firlar E, Kaelber JT, Ebright RH. Structural basis of Rho-dependent transcription termination. Nature. 2023.
  19. Monsen RC, Chua EYD, Hopkins JB, Chaires JB, Trent JO. Structure of a 28.5 kDa duplex-embedded G-quadruplex system resolved to 7.4 A resolution with cryo-EM. Nucleic Acids Res. 2023.
  20. Mueller AU, Chen J, Wu M, Chiu C, Nixon BT, Campbell EA, et al. A general mechanism for transcription bubble nucleation in bacteria. Proc Natl Acad Sci U S A. 2023.
  21. Park JU, Tsai AW, Rizo AN, Truong VH, Wellner TX, Schargel RD, et al. Structures of the holo CRISPR RNA-guided transposon integration complex. Nature. 2023.
  22. Patel A, Kumar S, Lai L, Chakravarthy C, Valanparambil R, Reddy ES, et al. Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response. Structure. 2023.
  23. Santiago-Frangos A, Henriques WS, Wiegand T, Gauvin CC, Buyukyoruk M, Graham AB, et al. Structure reveals why genome folding is necessary for site-specific integration of foreign DNA into CRISPR arrays. Nat Struct Mol Biol. 2023.
  24. Wang C, Molodtsov V, Sanders TJ, Marshall CJ, Firlar E, Kaelber JT, et al. Structural basis of archaeal FttA-dependent transcription termination. bioRxiv. 2023.
  25. Watkins MB, Wang H, Burnim A, Ando N. Conformational switching and flexibility in cobalamin-dependent methionine synthase studied by small-angle X-ray scattering and cryo-electron microscopy. bioRxiv. 2023.
  26. Weaver JW, Proshkin S, Duan W, Epshtein V, Gowder M, Bharati BK, et al. Control of transcription elongation and DNA repair by alarmone ppGpp. Nat Struct Mol Biol. 2023.
  27. Wilbon AS, Shen J, Ruchala P, Zhou M, Pan Y. Structural basis of ferroportin inhibition by minihepcidin PR73. PLoS Biol. 2023.
  28. Yang Y, Fritzsching KJ, He S, McDermott AE. Zinc Alters the Supramolecular Organization of Nucleic Acid Complexes with Full-Length TIA1. bioRxiv. 2023.

2022

  1. Capper MJ, Yang S, Stone AC, Vatansever S, Zilberg G, Mathiharan YK, Habib R, Hutchinson K, Schlessinger A, Mezei M, Osman R, Zhang B, Wacker D. Substrate Binding and Inhibition of the Anion Exchanger 1 Transporter. bioRxiv. 2022. [preprint].
  2. Chen J, Wang Q, Malone B, Llewellyn E, Pechersky Y, Maruthi K, Eng ET, Perry JK, Campbell EA, Shaw DE, Darst SA. Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat Struct Mol Biol. 2022;29(3):250-260.
  3. Finkelstein MT, Parker Miller E, Erdman MC, Fera D. Analysis of two cooperating antibodies unveils immune pressure imposed on HIV Env to elicit a V3-glycan supersite broadly neutralizing antibody lineage. Front Immunol. 2022.
  4. Gobeil SMC, Henderson R, Stalls V, Janowska K, Huang X, May A, Speakman M, Beaudoin E, Manne K, Li D, Parks R, Barr M, Deyton M, Martin M, Mansouri K, Edwards RJ, Sempowski GD, Saunders KO, Wiehe K, Williams W, Korber B, Haynes BF, Acharya P. Structural diversity of the SARS-CoV-2 Omicron spike. bioRxiv. 2022.
  5. Henderson R, Zhou Y, Stalls V, Wiehe K, Saunders KO, Wagh K, et al. Structural basis for breadth development in a HIV-1 neutralizing antibody. bioRxiv. 2022.
  6. Kendall AK, Chandra M, Xie B, Wan W, Jackson LP. Improved mammalian retromer cryo-EM structures reveal a new assembly interface. bioRxiv. 2022.
  7. Klykov O, Kopylov M, Carragher B, Heck AJR, Noble AJ, Scheltema RA. Label-free visual proteomics: Coupling MS- and EM-based approaches in structural biology. Mol Cell. 2022.
  8. Koo CW, Tucci FJ, He Y, Rosenzweig AC. Recovery of particulate methane monooxygenase structure and activity in a lipid bilayer. Science. 2022.
  9. Laughlin ZT, Nandi S, Dey D, Zelinskaya N, Witek MA, Srinivas P, Nguyen HA, Kuiper EG, Comstock LR, Dunham CM, Conn GL. 50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA. Proc Natl Acad Sci U S A. 2022.
  10. Leonhardt SA, Purdy MD, Grover JR, Yang Z, Poulos S, McIntire WE, et al. CryoEM Structures of the Human HIV-1 Restriction Factor SERINC3 and Function as a Lipid Transporter. bioRxiv. 2022.
  11. Liang WG, Wijaya J, Wei H, Noble AJ, Mancl JM, Mo S, Lee D, Lin King JV, Pan M, Liu C, Koehler CM, Zhao M, Potter CS, Carragher B, Li S, Tang WJ. Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition. Nat Commun. 2022.
  12. Malone BF, Perry JK, Olinares PDB, Chen J, Appelby TK, Feng JY, Bilello JP, Ng H, Sotiris J, Ebrahim M, Chua EYD, Mendez JH, Eng ET, Landick R, Chait BT, Campbell EA, Darst SA. Structural basis for substrate selection by the SARS-CoV-2 replicase. bioRxiv. 2022.
  13. Nguyen BA, Afrin S, Singh V, Ahmed Y, Pedretti R, del Carmen Fernandez-Ramirez M, et al. Structural polymorphism of amyloid fibrils in cardiac ATTR amyloidosis revealed by cryo-electron microscopy. bioRxiv. 2022.
  14. Patel A, Kumar S, Lai L, Chakravarthy C, Valanparambil R, Reddy ES, et al. Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response. bioRxiv. 2022.
  15. Smith EM, Ferrell S, Tokars VL, Mondragon A. Structures of an active type III-A CRISPR effector complex. Structure. 2022.
  16. Trinh TKH, Catalano C, Guo Y. Membrane-active Polymers: NCMNP13-x, NCMNP21-x and NCMNP21b-x for Membrane Protein Structural Biology. bioRxiv. 2022.
  17. Tsai K, Stojkovic V, Lee DJ, Young ID, Szal T, Klepacki D, Vazquez-Laslop N, Mankin AS, Fraser JS, Fujimori DG. Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics. Nat Struct Mol Biol. 2022.
  18. Wasmuth EV, Broeck AV, LaClair JR, Hoover EA, Lawrence KE, Paknejad N, Pappas K, Matthies D, Wang B, Feng W, Watson PA, Zinder JC, Karthaus WR, de la Cruz MJ, Hite RK, Manova-Todorova K, Yu Z, Weintraub ST, Klinge S, Sawyers CL. Allosteric interactions prime androgen receptor dimerization and activation. bioRxiv. 2022. [preprint].
  19. Wilbon AS, Shen J, Ruchala P, Zhou M, Pan Y. Structural basis of ferroportin inhibition by minihepcidin PR73. bioRxiv. 2022.
  20. Yelshanskaya MV, Patel DS, Kottke CM, Kurnikova MG, Sobolevsky AI. Opening of glutamate receptor channel to subconductance levels. Nature. 2022.
  21. Yin Y, Zhang F, Feng S, Butay KJ, Borgnia MJ, Im W, et al. Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP(2). Science. 2022.
  22. Yin Z, Bird JG, Kaelber JT, Nickels BE, Ebright RH. Structural basis of transcription antitermination by Qλ: NusA induces refolding of Qλ to form nozzle for RNA polymerase exit channel. bioRxiv. 2022. [preprint]
  23. Yu Y, Li S, Ser Z, Kuang H, Than T, Guan D, Zhao X, Patel DJ. Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clamping enabled by multi-subunit conformational changes. Proc Natl Acad Sci U S A. 2022.
  24. Zhao Y, Roy K, Vidossich P, Cancedda L, De Vivo M, Forbush B, Cao E. Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide. Nat Commun. 2022;13(1):2747.
  25. Zhao Y, Shen J, Wang Q, Ruiz Munevar MJ, Vidossich P, De Vivo M, et al. Structure of the human cation-chloride cotransport KCC1 in an outward-open state. Proc Natl Acad Sci U S A. 2022.
  26. Zheng X, Hu Z, Li H, Yang J. Structure of the human cone photoreceptor cyclic nucleotide-gated channel. Nat Struct Mol Biol. 2022;29(1):40-46.
  27. Zhou W, Yadav GP, Yang X, Qin F, Li C, Jiang QX. Cryo-EM structure-based selection of computed ligand poses enables design of MTA-synergic PRMT5 inhibitors of better potency. Commun Biol. 2022.
  28. Zhu J, Huang W, Zhao J, Huynh L, Taylor DJ, Harris ME. Structural and mechanistic basis for recognition of alternative tRNA precursor substrates by bacterial ribonuclease P. Nat Commun. 2022.
  29. Zimanyi CM, Kopylov M, Potter CS, Carragher B, Eng ET. Broadening access to cryoEM through centralized facilities. Trends Biochem Sci. 2022.

2021

  1. Catalano C, Ben-Hail D, Qiu W, Blount P, des Georges A, Guo Y. Cryo-EM Structure of Mechanosensitive Channel YnaI Using SMA2000: Challenges and Opportunities. Membranes. 2021;11(11):849.
  2. Cerutti G, Guo Y, Zhou T, Gorman J, Lee M, Rapp M, Reddem ER, Yu J, Bahna F, Bimela J, Huang Y, Katsamba PS, Liu L, Nair MS, Rawi R, Olia AS, Wang P, Zhang B, Chuang GY, Ho DD, Sheng Z, Kwong PD, Shapiro L. Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite. Cell Host Microbe. 2021:2021.2001.2010.426120.
  3. Cerutti G, Rapp M, Guo Y, Bahna F, Bimela J, Reddem ER, Yu J, Wang P, Liu L, Huang Y, Ho DD, Kwong PD, Sheng Z, Shapiro L. Structural basis for accommodation of emerging B.1.351 and B.1.1.7 variants by two potent SARS-CoV-2 neutralizing antibodies. Structure. 2021;29(7):655-663 e654.
  4. Chen K-E, Guo Q, Cui Y, Kendall AK, Hill TA, Hall RJ, Sacharz J, Norwood SJ, Xie B, Leneva N, Yang Z, Ghai R, Stroud DA, Fairlie D, Suga H, Jackson LP, Teasdale RD, Passioura T, Collins BM. De novo macrocyclic peptides for inhibiting, stabilising and probing the function of the Retromer endosomal trafficking complex. bioRxiv. 2021. [preprint]
  5. Feldman J, Bals J, Altomare CG, St Denis K, Lam EC, Hauser BM, Ronsard L, Sangesland M, Bracamonte Moreno T, Okonkwo V, Hartojo N, Balazs AB, Bajic G, Lingwood D, Schmidt AG. Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses. Sci Immunol. 2021:eabl5842.
  6. Gobeil SM, Janowska K, McDowell S, Mansouri K, Parks R, Manne K, Stalls V, Kopp MF, Henderson R, Edwards RJ, Haynes BF, Acharya P. D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction. Cell reports. 2021;34(2):108630.
  7. Gobeil SM, Janowska K, McDowell S, Mansouri K, Parks R, Stalls V, Kopp MF, Manne K, Li D, Wiehe K, Saunders KO, Edwards RJ, Korber B, Haynes BF, Henderson R, Acharya P. Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science. 2021;373(6555).
  8. He Y, Wang Y, Liu B, Helmling C, Sušac L, Cheng R, Zhou ZH, Feigon J. Structures of telomerase at several steps of telomere repeat synthesis. Nature. 2021;593(7859):454-459.
  9. Herrera NG, Morano NC, Celikgil A, Georgiev GI, Malonis RJ, Lee JH, Tong K, Vergnolle O, Massimi AB, Yen LY, Noble AJ, Kopylov M, Bonanno JB, Garrett-Thomson SC, Hayes DB, Bortz RH, 3rd, Wirchnianski AS, Florez C, Laudermilch E, Haslwanter D, Fels JM, Dieterle ME, Jangra RK, Barnhill J, Mengotto A, Kimmel D, Daily JP, Pirofski LA, Chandran K, Brenowitz M, Garforth SJ, Eng ET, Lai JR, Almo SC. Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis. ACS Omega. 2021;6(1):85-102.
  10. Klykov O, Gangwar SP, Yelshanskaya MV, Yen L, Sobolevsky AI. Structure and desensitization of AMPA receptor complexes with type II TARP gamma5 and GSG1L. Mol Cell. 2021.
  11. Kumar P, Cymes GD, Grosman C. Structure and function at the lipid-protein interface of a pentameric ligand-gated ion channel. Proc Natl Acad Sci U S A. 2021;118(23):e2100164118.
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2020

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