The next installment of the monthly methods-focused webinar series hosted by Stanford-SLAC CryoEM Center (S2C2) along with the National Center for CryoEM Access and Training (NCCAT), and the Pacific Northwest Center for CryoEM (PNCC) will be held on Thursday December 3, 2020 at 12 PM EDT / 9AM PDT

Dr. Sudha Chakrapani, Joseph T. Wearn, MD University Professor in Medicine at Case Western Reserve University will talk about her work Understanding gating mechanisms in Pentameric Ligand-Gated Ion Channels by CryoEM

Talk Abstract: My group is interested in structure, function and dynamics of pentameric ligand-gated ion channels (pLGICs). The pLGICs are central players in mediating fast synaptic transmission in the neuronal- and neuromuscular junctions. My talk will focus on two members of the pLGIC family: cation-selective serotonin (3A) receptors (5-HT3AR) and anion-selective glycine receptors (GlyR). I will present an overview of our rationale and strategies used to determine cryo-EM structures of full-length receptors in multiple conformational states. Findings from these studies have provided new molecular insights into gating mechanisms and drug modulation.

All are welcome to attend. Registration is at no-cost, but sign-up is required:

 We hope we will see you there!