• 1 week.

  • Morning lectures.

  • Afternoon practicals.

  • March 16-20, 2026.

  • students/postdocs $375.
    staff/PIs/professionals $450.
    industry $625.

  • Room/Accomodations NOT included.

Apply here.

Standard applications will close December 15, 2025. Late applications will be considered up to January 2, 2026.

Accepted applicants will be notified early January 2026.

For more information email nccatuseroffice [at] nysbc.org

see the 2024 shortcourse

Single Particle Short Course
March 16-20, 2026

NCCAT will offer a 1 week workshop focused on the theory and practice of single-particle analysis. The mornings are filled with lectures and stimulating round table discussions. The afternoons provide hands-on practicals to reinforce fundamental concepts and topics covered earlier in the day.

Short-course Agenda

Monday, March 16, 2026

Session Type Lecturer Topic
Morning Lecture 1 – Keynote Joachim Frank (Columbia University) Intro and overview of SPA
Morning Roundtable 1 students Flashtalks from students
Afternoon Lecture 2 SEMC staff Sample preparation for biological samples
Afternoon Practical 1 SEMC staff cryoEM sample prep and grid prep stations

Tuesday, March 17, 2026

Session Type Lecturer Topic
Morning Lecture 3a SEMC staff Microscopes and tools of the trade
Morning Lecture 3b SEMC staff Maintenance of cryoEM facilities
Afternoon Roundtable 2 SEMC staff Making use of local facilities and national centers
Afternoon Practical 2 SEMC staff Plunge freezing & TEM stations

Wednesday, March 18, 2026

Session Type Lecturer Topic
Morning Lecture 4a Fred Sigworth (Yale University) Algorithms and foundational math PartI:
derivation/explanation of the CTF, FTs.
Morning Lecture 4b Fred Sigworth (Yale University) Algorithms and foundational math PartII:
reconstruction, classification, and maximum likelihood.
Morning Lecture 5 David Jeruzalmi (City University of New York) Data Analysis and reconstruction workflow
Lunch Roundtable 3 Fred Sigworth & David Jeruzalmi Current and new algorithms to deal with SPA reconstruction
Afternoon Practical 3 SEMC staff Processing using cryoSPARC

Thursday, March 19, 2026

Session Type Lecturer Topic
Morning Lecture 6 Rich Hite (Memorial Sloan Kettering Cancer Center) Interpretation and Limitations of SPA
Morning Lecture 7 Andres Leschziner (Weill Cornell School of Medicine) Applications of cryoEM in the life sciences
Lunch Roundtable 4 Rich Hite & Andres Leschziner EM challenges and new frontiers
Afternoon Lecture 8 SEMC staff SPA experimental approaches using current technologies
Afternoon Practical 4 SEMC staff Autoloader TEMs and Krios data collection at a national center
Dinner all instructors Group dinner

Friday, March 20, 2026

Session Type Lecturer Topic
Morning Lecture 9 Oli Clarke (Columbia University) Fitting Atomic Models
Morning Lecture 10 Justin Flatt (RSCB/PDB) Best Practices for Cryo-EM Deposition and Validation 
Morning Roundtable 5 Oli Clarke & Justin Flatt Making cryoEM information accessible to the community.
Afternoon Practical 5 Oli Clarke Coot and model building

This workshop is limited up to 16 attendees and accepted applicants will receive instructions for payment of the course fee.

Apply here.

We will reach out to participants early January and waitlist participants by the end of January. For further inquires please email the NCCAT User Office.

Yes. This will be an in-person on-site workshop.

Yes. Parts of the workshop will be recorded. We will post all learning materials on our website.

Accepted participants will be charged for this course. Travel, food and housing costs are not covered. Instructions will follow after acceptance.

students/postdocs: $375.
staff/PIs/professionals: $450.
industry: $625.

If participants cancel or withdraw from the short course:

  • One month ahead of the workshop, there will be a refund of up to 66% minus processing fees,
  • Two weeks ahead of the workshop, there will be a refund of up to 50% minus processing fees,
  • One week ahead of the workshop, there will be no refunds.