• 3 days.

  • 1 day symposium.

  • 2 days of practicals.

  • November 2-4*, 2026.
    *optional follow-on day Nov. 5 for on-site data collection.

  • Registration fees:**
    students $125
    postdocs     $175.
    staff/PIs/professionals $250.
    industry $650.
    **travel awards available

  • Room and board NOT included.

Join the waitlist.

Applicants will be informed of acceptance on a rolling basis starting on September 14, 2026.
Applications after September 28, 2026 will be put on the waitlist.
Accepted applicants need to confirm registration and payment by October 26, 2026.
For more information email nccatuseroffice [at] nysbc.org

organizing committee:

Dan Decato (University of Montana)
Ed Eng (NYSBC) &
Christina Zimanyi (NYSBC)

program committee:

Josh Chen (University of North Carolina at Chapel Hill)
Michael Martynowycz (University of Buffalo)
Katie Spoth (University of Buffalo)
Ryan Donnelly (Yale University)

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3DED/MicroED Short Course
November 2-4, 2026

NYSBC, SEMC and NCCAT will offer a 3-day short course November 2-4, 2026. Day one of the course will encompass lectures that delve into the multiple steps of the MicroED workflow. Days 2 & 3 will have practicals in sample preparation, setting up a TEM for data collection, and data processing. For those that want further instruction and a chance to collect their own data, we will host a bonus day for independent practice on November 5. We held our first MicroED short course November 6-9, 2023 (https://nccat.nysbc.org/activities/courses/nccat-microed-2023/) for 18 participants, which resulted in an Acta C review to help disseminate knowledge to the broader scientific community. Our second iteration November 4-6, 2024 (https://nccat.nysbc.org/activities/courses/nccat-microed-2024/) built on lessons learned from the first workshop and further expanded the community of electron diffraction practitioners. Our third iteration November 3-5, 2025 (https://nccat.nysbc.org/activities/courses/nccat-microed-2025/) focused on advancing the field by creating sustainable communities of independent researchers. This offering will be our fourth iteration to promote accessibility and reduce bottlenecks.

sponsored by:

Short Course Agenda

*Current as of 10/20/26. Schedule is subject to change.

Monday, November 2, 2026

Day 1: Symposium

Time (ET) Topic Lecturer
9:30-10:00 Welcome and Introductions All attendees
10:00-10:30 Integrating an electron diffractometer into a small molecule crystallography facility Sebastian Krajewski, Yale University
10:30-11:00 Electron diffraction of biomacromolecules Michael Martynowycz, University of Buffalo
11:00-11:15 Coffee Break
11:15-11:45 Current topics: methods development in biological 3DED/MicroED Gerhard Hofer, Stockholm University
11:45-12:15 Technology development for electron diffraction Oliver Harder, Dectris
12:15 - 13:00 Group Photo & Lunch Lunch is provided
13:00-13:30 Walking tour of NYSBC Ed Eng, NYSBC
13:30-14:30 From images to structure: the process of small-molecule structure determination from 3DED/MicroED data Lukas Palatinus, Institute of Physics of the Czech Academy of Sciences (joining remotely)
14:30-14:50 Management of 3D ED/microED data at CCDC Natalie Johnson, Cambridge Crystallographic Data Centre
14:50-15:10 Management of 3D ED/microED data at wwPDB Chenghua Shao, Scientific Software Developer, RCSB Protein Data Bank
15:10-15:30 Open discussion on curation and metadata
15:30-15:50 Coffee/Tea Break
15:50-16:05 Making MicroED Accessible with the XtaLAB Synergy-ED Mark del Campo, Rigaku
16:05-16:20 Advances in electron diffraction and microscopy with MerlinEM Gearóid Mangan, Quantum Detectors
16:20-17:00 Roundtable All attendees
17:00-17:10 Debrief & overview of practical schedule Organizers
17:30 Group Dinner At Fumo Harlem

Tuesday, November 3, 2026

Day 2 Practicals: Data processing and sample preparation

Time (ET) Topic Lecturer
9:00-10:15 Data Processing Introduction and XDS Walkthru Michael Martynowycz, University of Buffalo
10:15-10:30 Break
10:30-12:00 Data Processing Practical Michael Martynowycz, University of Buffalo
12:00-13:00 Group Photo Take 2 and Lunch Lunch is Provided
13:00-14:00 Sample preparation station 1
14:00-14:15 Break
14:15-15:15 Sample preparation station 2
15:15-15:30 Break
15:30-16:30 Sample preparation station 3
16:30-16:40 Debrief
16:40 Reception Light Refreshments

Sample preparation stations. Attendees will rotate in small groups through all three stations.

Stations Topic Instructors
A Dry sample prep (small molecules) and autogrid clipping Dan Decato, Josh Chen, Jason de la Cruz, & Sebastian Krajewski
B Hydrated sample prep (biomacromolecules and plunge freezers) Bill Rice & Cody Gillman
C Focued Ion Beam (FIB) milling introduction & demo Mike Martynowycz, Daija Bobe, & Gabriella Angiulli

Wednesday, November 4, 2026

Day 3 Practicals: Data collection

Time (ET) Topic Lecturer
9:00-9:05 Morning introduction
9:05-9:35 Automation & machine learning in electron Diffraction Dmitry Eremin, University of Texas at Austin
9:35-9:50 Introduction to data collection interfaces Dan Decato, University of Montana
10:00-11:00 Data collection station 1
11:15-12:15 Data collection station 2
12:15-13:15 Lunch Lunch is Provided
13:15-14:15 Data collection station 3
14:30-15:30 Data collection station 4
15:30-15:45 break
15:45-16:30 Station 5: revisit your favorite station or join the data processing table
16:30-17:00 Debrief and wrap up NYSBC staff

Data collection stations. Attendees will rotate in small groups through four stations.

Stations Topic Instructors
A Setting up the microscope to collect good diffraction data Dan Decato & Sebastian Krajewski
B EPU-D workflow and collecting data Francisco Reyes, Josh Chen, & Ryan Donnelly
C Automation with Reyes and SerialEM Dmitry Eremin & Jason de la Cruz
D Direct detectors & lamella collection Mike Martynowycz & Bill Rice

Thursday, November 5, 2026

Day 4 Optional

additional informal instruction and an opportunity to work with your own sample

After acceptance, course participants will be required to submit a registration fee.

Join the waitlist.

We will reach out to accepted applicants in September and waitlisted applicants by October. For further inquires please email the NCCAT User Office.

The symposium on day one will be hybrid, but the short course will be an in-person on-site workshop.

See the 2023 offering of this workshop here.

See the 2024 offering of this workshop here.