The next installment of the monthly methods-focused webinar series hosted by the National Center for CryoEM Access and Training (NCCAT), along with the Pacific Northwest Center for CryoEM (PNCC), and the Stanford-SLAC CryoEM Center (S2C2) will be held on Thursday June 24, 2021 at 12 PM eastern / 9 AM pacific time
Dr. Aashish Manglik, Assistant Professor, Depts. of Pharmaceutical Chemistry & Anesthesia and Perioperative Care
University of California, San Francisco will present: Solving molecular puzzles in GPCR signaling with cryo-EM
Talk Abstract: Cryo-EM has revolutionized structural studies of G protein-coupled receptors over the past few years. More facile structure determination of active GPCRs has enabled the field to understand the molecular basis of receptor function at an unprecedented pace. I will discuss our efforts to use cryo-EM structure determination to interrogate GPCRs that remain orphan or otherwise poorly understood. We envision that cryo-EM-enabled structures of transmembrane proteins will usher in a new era of structural biology as a hypothesis generating tool for the dark matter of the proteome.