GUP2 Application instructions2018-10-16T01:54:26+00:00

GUP2 Application instructions

Chameleon Application requirements.

Applications will be limited to one page of text and one page of supporting data and figures. Key personnel named in the application must also submit an NIH Biosketch (https://grants.nih.gov/grants/forms/biosketch.htm). To download an application guide click here.

This initial cycle will support an early access program for use of the commercialized version of Spotiton: Chameleon. Researchers will be required to show cryoEM data of the current condition of the sample and justify how Chameleon use would assist. There are two (2) types of general use proposals:

  • GUP1: Data Collection
    Access for experienced users with pre-screened cryoEM samples in need of high-end instrument cryoEM time. For more information go here and to apply for this category of access go here.
  • GUP2: Sample preparation and screening
    Access for users in need of staff-assisted sample preparation and screening resources with the intent of a follow on high-end instrumentation session. During this early access period GUP2s will be primarily be offering use of Chameleon.

Accepted NCCAT users (and their PI’s if applicable) are required to sign a written agreement that they will comply with all NIH data sharing, reporting and publication policies. The written agreement will also outline other requirements and policies for NCCAT access so as to manage expectations as transparently as possible.

Application process

The initial round of proposals will be for General User Proposal 2 (GUPs) for Chameleon access. We have a quarterly call for applications, reviewed and ranked by a User Review Committee (URC), which is a peer review committee. Projects requiring multiple days and many sessions will be given extra scrutiny and will have to meet a high standard for preliminary data.

Users proposals are scored in the following categories: (i) scientific impact; (ii) scientific feasibility; (iii) technical feasibility; (iv) NCCAT resources requested; (v) geographical demographics. The URC will score these aspects on a scale of 1-5 and also have the option to provide additional comments.

A request for access proposal will expire in three (3) cycles or when the requested amount of time recommended by peer review has been used, whichever comes first. General user projects or applications will expire in two (2) years. After that point users will have to submit a new project to submit additional request for access applications/proposals against.

The content of proposal will be kept confidential by the reviewer or relevant committees. A user may specify individuals that pose a potential conflict and exclude them from the external review committee.

Categories for review

The user review committee (URC) will score with respect to five (5) different categories.
(i) scientific impact: Scientific and technological importance.
(ii) scientific feasibility: Fit as a cryoEM project versus another structural biology/biophysical approach given that standard cryoEM techniques have not yielded results.
(iii) technical feasibility: Describe the previous cryoEM results (2D, 3D & reconstructions) and clarify the reason high resolution reconstructions were not obtained.
(iv) NCCAT resources requested: Justify the use of Chameleon and highlight specifically how would Chameleon addresses the issues with the sample.
(v) geographical demographics or need: Resources available at home institution and geographical proximity to similar resources requested.

Note: Geographical diversity, need for access by under-served or under-represented institutions, the extent of requested support, and other options available to the users or the trainees, will be taken into account in setting priorities.

These scores will be combined and averaged for a final proposal score from 1 (excellent) to 5 (poor).

Possible scores

Scores are on a scale from 1 (excellent) to 5 (poor).

Score Title Description
1 Excellent Highly innovative research of great scientific or technological importance. Access to NCCAT is integral to the success of the work.
2 Good High quality research with the potential for making an important contribution to a specific field, scientific discipline, or technical development project. Use of NCCAT resources is important to a successful outcome of the work.
3 Satisfactory Interesting research likely to produce results or incremental technological advances. The work will benefit from access to NCCAT.
4 Needs improvement Research may not significantly impact a specific field, scientific discipline, or technological area. Proposed work would also be able to be completed in other facilities including the home institution of the user.
5 Poor / Unsatisfactory Not well-planned or not feasible. The need for use of a national center is not clear.
NR No Review Insufficient information to base a review.
Note: Scored proposals that have not been assigned time will automatically be forwarded to the next cycle with an improvement of 0.2. Proposals will be forwarded for a maximum of two (2) times for a maximum improvement of 0.4.